BID-dependent and BID-independent pathways for BAX insertion into mitochondria
نویسندگان
چکیده
منابع مشابه
Bid, but not Bax, regulates VDAC channels.
During apoptosis, cytochrome c is released from mitochondria into the cytosol, where it participates in caspase activation. Various and often conflicting mechanisms have been proposed to account for the increased permeability of the mitochondrial outer membrane that is responsible for this process. The voltage-dependent anion channel (VDAC) is the major permeability pathway for metabolites in t...
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Animal models suggest that Bax and Bak play an essential role in the implementation of apoptosis and as a result can hinder tumorigenesis. We analyzed the expression of these proteins in 50 human glioblastoma multiforme (GBM) tumors. We found that all the tumors expressed Bak, while three did not express Bax. In vitro, Bax-deficient GBM (BdGBM) exhibited an important resistance to various apopt...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2000
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400739